Interactive Non-monotonicity Explorer

The figure below can be used to explore how changing the wild type values of Ka and/or Ki by different factors (θ or θ1/θ2), keeping all other parameters between the mutant and wild-type the same, can result in non-monotonic behavior of ∆F. See the supplement for a more detailed definition of the non-monotonic dependence. This figure was generated using the Bokeh interactive plotting framework and the code used to generate it can be accessed via the code page of this website.

Bokeh Plot