| Chapter 1 | Why: Biology by the Numbers |
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| Chapter 2 | What and Where: Construction Plans for Cells and Organisms |
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| Chapter 3 | When: Space and Time Across Many Scales |
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| Chapter 4 | Who: “Bless the Little Beasties” |
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| Chapter 5 | Mechanical and Chemical Equilibrium in the Living Cell |
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| Chapter 6 | Entropy Rules! |
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| Chapter 7 | Two-State Systems: From Ion Channels to Cooperative Binding |
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| Chapter 8 | Random Walks and the Structure of Macromolecules |
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| Chapter 9 | Electrostatics for Salty Solutions |
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| Chapter 10 | Beam Theory: Architecture for Cells and Skeletons |
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| Chapter 11 | Biological Membranes: Lie in Two Dimensions |
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| Chapter 12 | The Mathematics of Water |
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| Chapter 13 | A Statistical View of Biological Dynamics |
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| Chapter 14 | Life in Crowded and Disordered Environments |
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| Chapter 15 | Rate Equations and Dynamics in the Cell |
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| Chapter 16 | Dynamics of Molecular Motors |
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| Chapter 17 | Biological Electricity and the Hodgkin-Huxley Model |
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| Chapter 18 | Light and Life |
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| Chapter 19 | Organization of Biological Networks |
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| Chapter 20 | Biological Patterns: Order in Space and Time |
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| Chapter 21 | Sequences, Specificity, and Evolution |
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| Chapter 22 | Whither Physical Biology? |
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