Optical Tweezers:

The wonder of Brownian motion in a harmonic trap.

Small polystyrene beads are trapped using optical gradient forces from a focused laser. These images are then loaded into a script which looks at the position of the bead in each frame; to the computer each framed is a complicated landscape.
Taken together the distribution of positions for the bead maps out the probability distribution of the bead in the trap. Using the probablity distribution one can find the energy landscape to which the bead was originally subjected.